Reminder to enroll in MTF ASAP!

NCPA December 11, 2025

You have probably received an email from the Centers for Medicare & Medicaid Services (CMS) on enrolling in the Medicare Transaction Facilitator (MTF) of the Medicare Drug Price Negotiation Program (MDPNP). If you are going to participate in any Medicare Part D network for next year, you must enroll in the MTF Data Module (MTF-DM) to receive your manufacturer refund payments. We encourage you to become familiar with the process before enrolling.

Here are some things to know:

1. You can watch an intro to the MTF on CMS' dispenser homepage here.

2. You can view a FAQ from CMS on the MTF here.

3. You can contact CMS at [email protected] with any questions. Additional support options can be found at https://mtf.helpdesk.cms.gov/home.

4. Before enrollment, you should make sure your NCPDP profile is accurate and updated.

5. Before enrollment, pharmacies need to know which functions, such as central pay or reconciliation services, they want to assign to any third-party support entities such as PSAOs or reconciliation vendors.

6. During enrollment pharmacies will need to sign a legal agreement, so proceed with caution and be sure to carefully review and have your legal counsel review.

7. During enrollment, identify as having "material cashflow concerns," as manufacturers can provide pharmacies with a plan for mitigating their cashflow concerns.

We strongly urge you to enroll before Jan. 1, 2026, though there is no hard deadline to complete enrollment (it will be ongoing to accommodate new pharmacies, for example). It will take approximately one hour and you will have to provide banking information.

Additional CMS resources:

  • CMS pharmacy toolkit on the MTF of the MDPNP. This resource includes a link and instructions to enroll, other resources for pharmacies, and reminders about how to keep your NCPDP data up to date.

  • CMS webinar to NCPA members on enrollment in the MTF. The webinar can be found here.

  • Various CMS MTF resources available here, including the MTF Enrollment Quick Guide to the CMS Help Desk website under the Browse Resources section. This is designed to assist pharmacies, other dispensing entities, and third-party support entities with the MTF enrollment process.

For NCPA advocacy on the MDPNP and on the Inflation Reduction Act generally, click here.

NCPA